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  • Aciclovir (INN)or acyclovir (USAN, former BAN), chemical name acycloguanosine, is a guanine analogue antiviral drug.
  • Aciclovir was seen as the start of a new era in antiviral therapy.
    Aciclovir differs from previous nucleoside analogues in that it contains only a partial nucleoside structure.
  • Acyclovir is poorly water soluble and has poor oral bioavailability.
    Acyclovir is available with a prescription under the brand name Zovirax.
  • Acyclovir is prescribed as a cream or ointment (topical use), oral tablets, or intravenous liquid.
  • Acyclovir-resistant pools of HSV typically represent heterogeneous mixtures of virus, and the antiviral-susceptibility curves and thymidine kinase biochemical assays of a given strain reflect the net composition of that pool.
  • Acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, a nucleotide analogue.
  • The comparability of systemic aciclovir exposure at steady state in immunocompromised patients has been evaluated.
  • Two common hydrolytic enzymes were used as the catalysts for the transesterification of acyclovir.
  • The antiviral action of acyclovir involves its enzymatic conversion into the triphosphate of acycloguanosine 9-[(2-hydroxyethoxy)methyl]guanine}.
  • Acyclovir {9-[(2-hydroxyethoxy)methyl]guanine} is a synthetic purine nucleoside analog derived from guanine.
  • Acylovir is indicated for the treatment of HSV and VZV infections.
  • Taking acyclovir with food may decrease stomach upset.
    Acyclovir is used to treat infections caused by herpes viruses.
  • Acyclovir is a purine nucleoside analogue with effects against human herpesvirus infections.
  • Antiviral nucleoside acyclovir acts as a potential drug candidate for improving antiviral efficacy against herpetic epithelial and stromal keratitis.
  • The use of acyclovir (ACV) has become an established part of clinical practice.
  • HPLC technique is used for the determination of guanine nucleoside derivative acyclovir in serum, saliva and urine.
  • Inderting Acyclovir twice a day by melt extrusion technique helps to improve patient complience using hydroxypropylcellulose as thermoplastic polymer.
  • Suppression and reactivation of viral replication were evaluated by functional and molecular techniques.
  • The effect of solvent polarity on the keto–enol tautomerism of N- and O-acetylated acyclovir derivatives has been studied through different spectroscopic technique.
  • It has been reported that A 50-year-old woman developed rapidly progressive acute renal failure on the first day after the administration of intravenous acyclovir for acute left retinal necrosis.
  • The proposed switching of oral acyclovir from prescription to over-the-counter (OTC) status for the 5-day episodic treatment of genital herpes was considered by a consensus panel.
  • The antiviral activity of acyclovir requires that it first be converted to its monophosphate derivative by viral thymidine kinase.
  • Adverse effects have been reported in patients receiving both large and low doses of acyclovir by both rapid and slow intravenous
    infusions as well as with oral use.
General Information
  • Aciclovir - Antiviral Information
  • Acyclovir Information
  • Acyclovir (Zovirax®)/Valacyclovir (Valtrex®) and Pregnancy
  • Aciclovir (topical)
  • About Acyclovir
  • Aciclovir

Company Profiles

  • Company from Ontario
  • Company from Singapore
  • Company from Taiwan
  • Company from Turkey
  • Company from USA


  • Consultant from India
  • Consultant from New York
  • Consultant from USA
  • Consultant from Washington


  • Comparable aciclovir exposures produced by oral valaciclovir and intravenous aciclovir in immunocompromised cancer patients
  • Development of Effective Antiviral agents of a new type
  • Electroporation and Transcutaneous sampling of acyclovir
  • Enzyme-catalyzed Transesterification of Unusual Substrate: Synthesis of Acyclovir and L-ascorbic Acid (Vitamin C) Vinyl Esters
  • Iontophoretic Delivery of Cream and Gel Formulations of Acyclovir
  • Acyclovir: Mechanism of Action
  • Synthesis and structural characteristics of metal–acyclovir (ACV) complexes: [Ni(or Co)(ACV)2(H2O)4]Cl2?2ACV, [Zn(ACV)- Cl2(H2O)], [Cd(ACV)Cl2]?H2O and [{Hg(ACV)Cl2}x]. Recognition of acyclovir by Ni–ACV
  • Practical syntheses of antiviral nucleosides


  • Application for the inclusion of Aciclovir eye ointment in the WHO list of essential medicines
  • Acyclovir Levels in Serum and Cerebrospinal Fluid after Oral Administration of Valacyclovir
  • Randomized clinical trial of ganciclovir vs acyclovir for prevention of cytomegalovirus antigenemia after allogeneic transplantation
  • Iontophoretic Application of Acyclovir Gel to Treat Cold Sores
  • In Vivo Antiviral Efficacy of a Dipeptide Acyclovir Prodrug, Val-Val-Acyclovir, against HSV-1 Epithelial and Stromal Keratitis in the Rabbit Eye Model
  • In Vitro Evaluation of Percutaneous Absorption of an Acyclovir Product using Intact and Tape-stripped Human Skin
  • Co-Infection of Acyclovir-Resistant and Acyclovir-Sensitive Herpes simplex Type 2 Virus Strains in BS-C-1 Cells
  • The determination of acyclovir in sheep serum, human serum, saliva and urine by HPLC
  • Twice a day Ocular inserts of Acyclovir  by melt extrusion technique
  • Mathematical modelling of preparation of acyclovir liposomes: reverse phase evaporation method.
  • Molecular Analysis of Acyclovir-lnduced Suppression of HSV-1 Replication in Rabbit Corneal Cells
  • Nephrotoxicity of Acyclovir and Ganciclovir in Rats: Evaluation of Glomerular Hemodynamics
  • Spectroscopic investigation of the tautomeric equilibria in the guanine derivatives of acyclovir
  • Potentiating Effect of Mizoribine on the Anti-Herpes Virus Activity of Acyclovir
  • Potentiation of Antiviral Activity of Acyclovir by Polyene Macrolide Antibioticst
  • Effect of Acyclovir on Viral Protein Synthesis in Cells Infected with Herpes Simplex Virus Type 1
  • Effects of Acyclovir and Its Metabolites on Purine Nucleoside Phosphorylase
  • Differential Effects of Acyclovir and 9-(1,3-Dihydroxy-2-Propoxymethyl)Guanine on Herpes Simplex Virus and Epstein-Barr Virus in a Dually Infected Human Lymphoblastoid Cell Line
  • The Effect of the Interaction of Acyclovir with Zidovudine on Progression to AIDS and Survival: Analysis of Data in the Multicenter AIDS Cohort Study
  • Ramsay Hunt Syndrome Treated with Oral Acyclovir

Material Safety Data Sheet

  • Acycloguanosine
  • Acyclovir
  • Zovirax Capsules
  • Acyclovir , [Side-Chain-2-3H]
  • Acyclovir Sodium Injection


  • Acyclovir Topical Cream
  • ACICLOVIR AL cream 2g 5%
  • Aciclovir 250MG Powder
  • Lovir Tablets (Genric Zovirax)


  • Acyclovir Diester Derivatives
  • Acyclovir Antiviral gel Composition
  • Method for Preparing Acyclovir prodrugs
  • Oral Acyclovir Delivery
  • Method of Producing Acyclovir
  • Aqueous Acyclovir Product
Risk Management
  • Prescription of pharmaceutical benefits by authorised Optometrists Determination under subsections 85A(1) and (2) and 88(1C) of the National Health Act

  • Acyclovir and Valacyclovir Pregnancy Registries

  • Fetal Risk Summary

  • Controversies in Management: Acyclovir for childhood chickenpox

  • Management Strategies for Herpes Zoster and Postherpetic Neuralgia


  • Acyclovir-induced nephrotoxicity in a patient with acute retinal necrosis
  • Perspectives on Switching Oral Acyclovir from Prescription to Over-the-Counter Status: Report of a Consensus Panel
  • Practice parameter: Steroids, acyclovir, and surgery for Bell’s palsy (an evidence-based review)
  • Recurrent Acyclovir-Resistant Genital Herpes in an Immunocompetent Patient
  • Acyclovir Induced Reversible Renal Failure in an Immunocompromised Child with Extensive Cutaneous Herpes Zoster
  • Full Clinical Recovery after Topical Acyclovir Treatment of Epstein-Barr Virus Associated Cutaneous B-Cell Lymphoma in Patient with Mycosis Fungoides
  • Suppliers of Acyclovir
  • Acyclovir Exporters
  • Acyclovir Manufacturer / Suppliers
  • Acyclovir Suppliers Worldwide
  • Selling Leads of Acyclovir
  • Acyclovir Suppliers

Primary Information Services
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 Phone: 91 44 22421080 
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