Technology, MSDS, Process, Product, Videos, Consultancy, Report,
- Phosphorylation is the
addition of a phosphate (PO43-) group to a protein or other organic
turns many protein enzymes on and off, thereby altering their
function and activity.
- It is the most
essential post-translational modification of proteins, modulates
conformation, stability, trafficking, interaction and cellular
dynamics and plasticity.
- It changes the
activity of important signaling proteins. By controlling the
activity of these proteins, kinases control most cellular processes
including metabolism, transcription, cell cycle progression, cell
movement, apoptosis .
- Phosphorylation is a
fundamental covalent PTM that regulates the function,
localization and binding specificity of target proteins.
Protein Phosphorylation in particular plays a significant role in a
wide range of cellular processes.
- Its prominent role in
biochemistry is the subject of a very large body of
research (as of March 2012, the Medline database returns nearly
200,000 articles on the
subject, largely on protein phosphorylation).
phosphorylation of proteins is an important regulatory mechanism
occurs in both prokaryotic and eukaryotic organisms.
on serine is the most common, followed by threonine. Tyrosine
- ATP, the "high-energy"
exchange medium in the cell, is synthesized in the
mitochondrion by addition of a third phosphate group to ADP in a
process referred to as oxidative phosphorylation.
- It is the most common
mechanism of regulating protein function and transmitting signals
throughout the cell. While phosphorylation has been observed in
bacterial proteins, it is considerably more pervasive in eukaryotic
cells. It is estimated that one-third of the proteins in the human
proteome are substrates for phosphorylation at some point.
- ATP is also
synthesized by substrate-level
phosphorylation during glycolysis.
phosphorylation is the most ubiquitous post-translational
modification (PTM), and plays important role in most of biological
- Identification of
site-specific phosphorylated substrates is fundamental for
understanding the molecular mechanisms of phosphorylation.
- Fact Sheet-Protein
- What is
- How is Phosphorylation
- Origins of Protein
- Phosphorylation Site
- Identification of
- Phosphorylation of
Phosphorylation reagent II.
- Survival marker:
Signal stain phospho-Akt(Ser473) IHC detection kit.
phosphorylation process control brain aromatase in quail.
analysis by mass spectrometry.
- Mobility shift
detection of phosphorylated proteins.
- A New method of
phos-phorylation & synthesis of some phosphate esters of biological
- Phosphorylation and
processing of the Quorum sensing molecule.
- Kinetic Analysis of
- ATP synthesis.
- Synthesis and
phosphorylation of chromatin associated proteins.
- Quantitative methods
for the analysis of protein phosphorylation.
- Mechanism of
- Consultancy from
- Consultancy from New
- Consultancy from
Cascade-Signal Transduction Pathway.
phosphorylation and Chemiosmosis.
- Information about
- Studies on the
phosphorylation and dephosphorylation reactions.
- A Paxillin tyrosine
phosphorylation switch regulates the assembly and form of
- Src kinase regulation
by phosphorylation and dephosphorylation.
- A model for a network
- Histone H3
phosphorylation is required for initiation of mammalian chromosome.
- Geometry of Multisite
phosphorylation dynamics in signaling networks.
resources for protein phosphorylation.
- Effect of protein
phos-phorylation on the functional activity of photosystem2.
- Estrogen receptor
- Principles of protein
- Postsynaptic protein
- Anti-diabetic drugs
inhibit obesity-linked phosphorylation.
- Chloroplast protein
- Multiplex assays for
signal transduction research.
phosphorylation antibody pair.
- Approach to analysis
of protein phosphorylation.
reaction in protein kinase A.
- Protein tyrosine
phosphorylation in plants.
- Phosphorylation at the
- Phosphorylation by
alkaline phosphatase: use of the enzyme in cascade reactions.
- Online literature
mining tool for protein phosphorylation.
- Investigation on ATP
synthesis via oxidative phosphorylation .
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